Prof. Dr. med.
Christian Kupatt
Geschäftsführender Oberarzt
089 4140 2947

Forschung Veröffentlichungen Mol Int.


Veröffentlichungen
 
 

Diabetes Mellitus-Induced Microvascular Destabilization in the Myocardium.

Hinkel R1, Hoewe A2, Renner S3, Ng J2, Lee S2, Klett K4, Kaczmarek V4, Moretti A5, Laugwitz KL5, Skroblin P6, Mayr M6, Milting H7, Dendorfer A8, Reichart B8, Wolf E3, Kupatt C9.
J Am Coll Cardiol. 2017 Jan 17;69(2):131-143. doi: 10.1016/j.jacc.2016.10.058.

Methods Mol Biol. 2017;1521:249-260.

Hinkel R1Kupatt C

 


Pim1 Overexpressing ckit+ Cardiac Stem Cells in Cardiac Regeneration: Preconditioning as Next-Generation Stem Cell Therapy?

Hinkel R.

J Am Coll Cardiol. 2016 Dec 6;68(22):2465-2466. doi: 10.1016/j.jacc.2016.09.924. No abstract available.

Jochheim D, Zadrozny M, Theiss H, Baquet M, Maimer-Rodrigues F, Bauer A, Lange P, Greif M, Kupatt C, Hausleiter J, Hagl C, Massberg S, Mehilli J.

Attenuation of cardiac hypertrophy by G-CSF is associated with enhanced migration of bone marrow-derived cells.

EuroIntervention. 2015 Jun 22;11(2):214-20. doi: 10.4244/EIJV11I2A40.

Huber BC, Beetz NL, Laskowski A, Ziegler T, Grabmaier U, Kupatt C, Herbach N, Wanke R, Franz WM, Massberg S, Brunner S.

J Cell Mol Med. 2015 May;19(5):1033-41. doi: 10.1111/jcmm.12494. Epub 2015 Mar 8.

 

Thymosin-β4-mediated therapeutic neovascularization: role of the PI3K/AKT pathway.

Trenkwalder T, Deindl E, Bongiovanni D, Lee S, Schunkert H, Kupatt C, Hinkel R.

Expert Opin Biol Ther. 2015 Feb 4:1-11. [Epub ahead of print]

 

Thymosin β4 attenuates microcirculatory and hemodynamic destabilization in sepsis.

Bongiovanni D, Ziegler T, D'Almeida S, Zhang T, Ng JK, Dietzel S, Hinkel R, Kupatt C.

Expert Opin Biol Ther. 2015 Jan 21:1-8. [Epub ahead of print]

 

Annexin A1 counteracts chemokine-induced arterial myeloid cell recruitment.

Drechsler M, de Jong R, Rossaint J, Viola JR, Leoni G, Wang JM, Grommes J, Hinkel R, Kupatt C, Weber C, Döring Y, Zarbock A, Soehnlein O.

Circ Res. 2015 Feb 27;116(5):827-35. doi: 10.1161/CIRCRESAHA.116.305825. Epub 2014 Dec 17.

 

Adeno-associated viral vector 2.9 thymosin ß4 application attenuates rejection after heart transplantation: results of a preclinical study in the pig.

Postrach J, Schmidt M, Thormann M, Thein E, Burdorf L, Reichart B, Sotlar K, Walz C, Faber C, Bauer A, Schmoeckel M, Kupatt C, Hinkel R.

Transplantation. 2014 Oct 27;98(8):835-43. doi: 10.1097/TP.0000000000000327.

 

Targeting microRNAs for cardiovascular therapeutics in coronary artery disease.

Hinkel R, Ng JK, Kupatt C.

Curr Opin Cardiol. 2014 Nov;29(6):586-94. doi: 10.1097/HCO.0000000000000107. Review.

 

CT-angiography-based evaluation of the aortic annulus for prosthesis sizing in transcatheter aortic valve implantation (TAVI)-predictive value and optimal thresholds for major anatomic parameters.

Schwarz F, Lange P, Zinsser D, Greif M, Boekstegers P, Schmitz C, Reiser MF, Kupatt C, Becker HC.

PLoS One. 2014 Aug 1;9(8):e103481. doi: 10.1371/journal.pone.0103481. eCollection 2014.

 

[Role of bone marrow-derived CD133+ stem cells in cardiac regeneration: from experimental to clinical trials].

Bongiovanni D, Bassetti B, Kupatt C, Pompilio G.

G Ital Cardiol (Rome). 2014 Jun;15(6):355-62. doi: 10.1714/1582.17278. Review. Italian.

 

Contrast-induced acute kidney injury after computed tomography prior to transcatheter aortic valve implantation.

Jochheim D, Schneider VS, Schwarz F, Kupatt C, Lange P, Reiser M, Massberg S, Gutiérrez-Chico JL, Mehilli J, Becker HC.

Clin Radiol. 2014 Oct;69(10):1034-8. doi: 10.1016/j.crad.2014.05.106. Epub 2014 Jul 10.

 

MRTF-A controls vessel growth and maturation by increasing the expression of CCN1 and CCN2.

Hinkel R, Trenkwalder T, Petersen B, Husada W, Gesenhues F, Lee S, Hannappel E, Bock-Marquette I, Theisen D, Leitner L, Boekstegers P, Cierniewski C, Müller OJ, le Noble F, Adams RH, Weinl C, Nordheim A, Reichart B, Weber C, Olson E, Posern G, Deindl E, Niemann H, Kupatt C.

Nat Commun. 2014 Jun 9;5:3970. doi: 10.1038/ncomms4970.

 

Fibrinolysis for patients with intermediate-risk pulmonary embolism.

Meyer G, Vicaut E, Danays T, Agnelli G, Becattini C, Beyer-Westendorf J, Bluhmki E, Bouvaist H, Brenner B, Couturaud F, Dellas C, Empen K, Franca A, Galiè N, Geibel A, Goldhaber SZ, Jimenez D, Kozak M, Kupatt C, Kucher N, Lang IM, Lankeit M, Meneveau N, Pacouret G, Palazzini M, Petris A, Pruszczyk P, Rugolotto M, Salvi A, Schellong S, Sebbane M, Sobkowicz B, Stefanovic BS, Thiele H, Torbicki A, Verschuren F, Konstantinides SV; PEITHO Investigators.

N Engl J Med. 2014 Apr 10;370(15):1402-11. doi: 10.1056/NEJMoa1302097.

 

Modifying effect of dual antiplatelet therapy on incidence of stent thrombosis according to implanted drug-eluting stent type.

Camenzind E, Boersma E, Wijns W, Mauri L, Rademaker-Havinga T, Ordoubadi FF, Suttorp MJ, Al Kurdi M, Steg PG; PROTECT Steering Committee and Investigators.

Eur Heart J. 2014 Aug 1;35(29):1932-48. doi: 10.1093/eurheartj/ehu084. Epub 2014 Mar 13.

 

Feasibility of dynamic CT-based adenosine stress myocardial perfusion imaging to detect and differentiate ischemic and infarcted myocardium in an large experimental porcine animal model.

Bamberg F, Hinkel R, Marcus RP, Baloch E, Hildebrandt K, Schwarz F, Hetterich H, Sandner TA, Schlett CL, Ebersberger U, Kupatt C, Hoffmann U, Reiser MF, Theisen D, Nikolaou K.

Int J Cardiovasc Imaging. 2014 Apr;30(4):803-12. doi: 10.1007/s10554-014-0390-3. Epub 2014 Feb 26.

 

Reduction of pacemaker implantation rates after CoreValve® implantation by moderate predilatation.

Lange P, Greif M, Vogel A, Thaumann A, Helbig S, Schwarz F, Schmitz C, Becker C, D'Anastasi M, Boekstegers P, Pohl T, Laubender RP, Steinbeck G, Kupatt C.

EuroIntervention. 2014 Feb;9(10):1151-7. doi: 10.4244/EIJV9I10A195.

 

VEGF-B: a more balanced approach toward cardiac neovascularization?

Kupatt C, Hinkel R.

EMBO Mol Med. 2014 Mar;6(3):297-8. doi: 10.1002/emmm.201303730. Epub 2014 Feb 12.

 

Transcutaneous aortic valve replacement with the Edwards SAPIEN XT and Medtronic CoreValve prosthesis under fluoroscopic guidance and local anaesthesia only.

Greif M, Lange P, Näbauer M, Schwarz F, Becker C, Schmitz C, Pohl T, D'Anastasi M, Boekstegers P, Massberg S, Kupatt C.

Heart. 2014 May;100(9):691-5. doi: 10.1136/heartjnl-2013-304918. Epub 2014 Jan 23.

 

Myocardial CT perfusion imaging in a large animal model: comparison of dynamic versus single-phase acquisitions.

Schwarz F, Hinkel R, Baloch E, Marcus RP, Hildebrandt K, Sandner TA, Kupatt C, Hoffmann V, Wintersperger BJ, Reiser MF, Theisen D, Nikolaou K, Bamberg F.

JACC Cardiovasc Imaging. 2013 Dec;6(12):1229-38. doi: 10.1016/j.jcmg.2013.05.018. Epub 2013 Oct 23.

 

Edwards Sapien XT valve placement as treatment option for aortic regurgitation after transfemoral CoreValve implantation: a multicenter experience.

Diemert P, Lange P, Greif M, Seiffert M, Conradi L, Massberg S, Blankenberg S, Reichenspurner H, Hagl C, Schmitz C, Schröfel H, Treede H, Schymik G, Kupatt C.

Clin Res Cardiol. 2014 Mar;103(3):183-90. doi: 10.1007/s00392-013-0632-8. Epub 2013 Nov 20.

 

Randomized, controlled trial of ultrasound-assisted catheter-directed thrombolysis for acute intermediate-risk pulmonary embolism.

Kucher N, Boekstegers P, Müller OJ, Kupatt C, Beyer-Westendorf J, Heitzer T, Tebbe U, Horstkotte J, Müller R, Blessing E, Greif M, Lange P, Hoffmann RT, Werth S, Barmeyer A, Härtel D, Grünwald H, Empen K, Baumgartner I.

Circulation. 2014 Jan 28;129(4):479-86. doi: 10.1161/CIRCULATIONAHA.113.005544. Epub 2013 Nov 13.

 

Sick sinus syndrome in HCN1-deficient mice.

Fenske S, Krause SC, Hassan SI, Becirovic E, Auer F, Bernard R, Kupatt C, Lange P, Ziegler T, Wotjak CT, Zhang H, Hammelmann V, Paparizos C, Biel M, Wahl-Schott CA.

Circulation. 2013 Dec 17;128(24):2585-94. doi: 10.1161/CIRCULATIONAHA.113.003712. Epub 2013 Nov 11.

 

Inhibition of microRNA-92a protects against ischemia/reperfusion injury in a large-animal model.

Hinkel R, Penzkofer D, Zühlke S, Fischer A, Husada W, Xu QF, Baloch E, van Rooij E, Zeiher AM, Kupatt C, Dimmeler S.

Circulation. 2013 Sep 3;128(10):1066-75. doi: 10.1161/CIRCULATIONAHA.113.001904. Epub 2013 Jul 29.

 

Angiopoietin 2 mediates microvascular and hemodynamic alterations in sepsis.

Ziegler T, Horstkotte J, Schwab C, Pfetsch V, Weinmann K, Dietzel S, Rohwedder I, Hinkel R, Gross L, Lee S, Hu J, Soehnlein O, Franz WM, Sperandio M, Pohl U, Thomas M, Weber C, Augustin HG, Fässler R, Deutsch U, Kupatt C.

J Clin Invest. 2013 Jul 1. pii: 66549. doi: 10.1172/JCI66549. [Epub ahead of print]

 

Balloon valvuloplasty for treatment of cardiogenic shock in the era of surgical valve replacement and TAVI.

Theiss HD, Greif M, Steinbeck G, Kupatt C, Franz WM.

Intern Emerg Med. 2014 Apr;9(3):345-7. doi: 10.1007/s11739-013-0972-4. Epub 2013 Jul 4. No abstract available.

 

SDF-1 fused to a fractalkine stalk and a GPI anchor enables functional neovascularization.

Stachel G, Trenkwalder T, Götz F, El Aouni C, Muenchmeier N, Pfosser A, Nussbaum C, Sperandio M, Hatzopoulos AK, Hinkel R, Nelson PJ, Kupatt C.

Stem Cells. 2013 Sep;31(9):1795-805. doi: 10.1002/stem.1439.

 

Early vessel destabilization mediated by Angiopoietin-2 and subsequent vessel maturation via Angiopoietin-1 induce functional neovasculature after ischemia.

Qin D, Trenkwalder T, Lee S, Chillo O, Deindl E, Kupatt C, Hinkel R.

PLoS One. 2013 Apr 16;8(4):e61831. doi: 10.1371/journal.pone.0061831. Print 2013.

 

Effectiveness of automated quantification of pulmonary perfused blood volume using dual-energy CTPA for the severity assessment of acute pulmonary embolism.

Meinel FG, Graef A, Bamberg F, Thieme SF, Schwarz F, Sommer WH, Neurohr C, Kupatt C, Reiser MF, Johnson TR.

Invest Radiol. 2013 Aug;48(8):563-9. doi: 10.1097/RLI.0b013e3182879482.

 

Transfemoral access for valve in valve implantation of an Edwards Sapien XT valve in a stenotic tricuspid bioprosthesis under fluoroscopic guidance.

Greif M, Schramm R, Steinbeck G, Hagl C, Schmitz C, Kupatt C.

Can J Cardiol. 2013 Aug;29(8):1014.e3-4. doi: 10.1016/j.cjca.2012.11.027. Epub 2013 Feb 11.

Angiogenetic potential of Ad2/Hif-1α/VP16 after regional application in a preclinical pig model of chronic ischemia.

Hinkel R, Lebherz C, Fydanaki M, Wuchrer A, El-Aouni C, Thormann M, Thein E, Kupatt C, Boekstegers P.

Curr Vasc Pharmacol. 2013 Jan;11(1):29-37.

 

Partial inferior sternotomy and deep hypothermic circulatory arrest for rescue of a failed TAVI case: what does constitute 'inoperable'?

Schramm R, Mair H, Becker C, Schwarz F, Bombien R, Juchem G, Sodian R, Kupatt C, Schmitz C.

Thorac Cardiovasc Surg. 2013 Aug;61(5):431-4. doi: 10.1055/s-0032-1327762. Epub 2013 Jan 23.

 

Transcatheter aortic-valve endocarditis confirmed by transesophageal echocardiography.

Orban M, Sinnecker D, Mair H, Nabauer M, Kupatt C, Schmitz C, Massberg S, Laugwitz KL, Barthel P.

Circulation. 2013 Jan 15;127(2):e265-6. doi: 10.1161/CIRCULATIONAHA.112.109033. No abstract available.

 

Molecular and cellular mechanisms of thymosin β4-mediated cardioprotection.

Hinkel R, Trenkwalder T, Kupatt C.

Ann N Y Acad Sci. 2012 Oct;1269:102-9. doi: 10.1111/j.1749-6632.2012.06693.x.

 

Stent thrombosis and major clinical events at 3 years after zotarolimus-eluting or sirolimus-eluting coronary stent implantation: a randomised, multicentre, open-label, controlled trial.

Camenzind E, Wijns W, Mauri L, Kurowski V, Parikh K, Gao R, Bode C, Greenwood JP, Boersma E, Vranckx P, McFadden E, Serruys PW, O'Neil WW, Jorissen B, Van Leeuwen F, Steg PG; PROTECT Steering Committee and Investigators.

Lancet. 2012 Oct 20;380(9851):1396-405. doi: 10.1016/S0140-6736(12)61336-1. Epub 2012 Aug 27.

 

Transcatheter Edwards Sapien XT valve in valve implantation in degenerated aortic bioprostheses via transfemoral access.

Greif M, Lange P, Mair H, Becker C, Schmitz C, Steinbeck G, Kupatt C.

Clin Res Cardiol. 2012 Dec;101(12):993-1001. doi: 10.1007/s00392-012-0488-3. Epub 2012 Jun 23.

 

Transcatheter aortic valve implantation in dialysis patients.

Rau S, Wessely M, Lange P, Kupatt C, Steinbeck G, Fischereder M, Schönermarck U.

Nephron Clin Pract. 2012;120(2):c86-90. doi: 10.1159/000335781. Epub 2012 Feb 22.

 

Adjuvant early and late cardioprotective therapy: access to the heart.

Hinkel R, Boekstegers P, Kupatt C.

Cardiovasc Res. 2012 May 1;94(2):226-36. doi: 10.1093/cvr/cvs075. Epub 2012 Feb 7. Review.

 

Three-dimensional printing of models for preoperative planning and simulation of transcatheter valve replacement.

Schmauss D, Schmitz C, Bigdeli AK, Weber S, Gerber N, Beiras-Fernandez A, Schwarz F, Becker C, Kupatt C, Sodian R.

Ann Thorac Surg. 2012 Feb;93(2):e31-3. doi: 10.1016/j.athoracsur.2011.09.031.

 

Transcatheter aortic valve implantation in aortic coarctation.

Schramm R, Kupatt C, Becker C, Bombien R, Reichart B, Sodian R, Schmitz C.

Thorac Cardiovasc Surg. 2013 Jun;61(4):336-9. doi: 10.1055/s-0031-1295575. Epub 2012 Jan 3.

 

Accuracy of dynamic computed tomography adenosine stress myocardial perfusion imaging in estimating myocardial blood flow at various degrees of coronary artery stenosis using a porcine animal model.

Bamberg F, Hinkel R, Schwarz F, Sandner TA, Baloch E, Marcus R, Becker A, Kupatt C, Wintersperger BJ, Johnson TR, Theisen D, Klotz E, Reiser MF, Nikolaou K.

Invest Radiol. 2012 Jan;47(1):71-7. doi: 10.1097/RLI.0b013e31823fd42b.

 

Single-bolus tenecteplase plus heparin compared with heparin alone for normotensive patients with acute pulmonary embolism who have evidence of right ventricular dysfunction and myocardial injury: rationale and design of the Pulmonary Embolism Thrombolysis (PEITHO) trial.

Steering Committee.

Am Heart J. 2012 Jan;163(1):33-38.e1. doi: 10.1016/j.ahj.2011.10.003.

Mitochondrial thioredoxin reductase is essential for early postischemic myocardial protection.

Horstkotte J, Perisic T, Schneider M, Lange P, Schroeder M, Kiermayer C, Hinkel R, Ziegler T, Mandal PK, David R, Schulz S, Schmitt S, Widder J, Sinowatz F, Becker BF, Bauersachs J, Naebauer M, Franz WM, Jeremias I, Brielmeier M, Zischka H, Conrad M, Kupatt C.

Circulation. 2011 Dec 20;124(25):2892-902. doi: 10.1161/CIRCULATIONAHA.111.059253. Epub 2011 Dec 5.

 

Preconditioned endothelial progenitor cells reduce formation of melanoma metastases through SPARC-driven cell-cell interactions and endocytosis.

Defresne F, Bouzin C, Grandjean M, Dieu M, Raes M, Hatzopoulos AK, Kupatt C, Feron O.

Cancer Res. 2011 Jul 15;71(14):4748-57. doi: 10.1158/0008-5472.CAN-10-2449. Epub 2011 May 26.

 

Gene therapy for ischemic heart disease.

Hinkel R, Trenkwalder T, Kupatt C.

Expert Opin Biol Ther. 2011 Jun;11(6):723-37. doi: 10.1517/14712598.2011.570749. Epub 2011 Mar 25. Review.

 

Cotransfection of vascular endothelial growth factor-A and platelet-derived growth factor-B via recombinant adeno-associated virus resolves chronic ischemic malperfusion role of vessel maturation.

Kupatt C, Hinkel R, Pfosser A, El-Aouni C, Wuchrer A, Fritz A, Globisch F, Thormann M, Horstkotte J, Lebherz C, Thein E, Banfi A, Boekstegers P.

J Am Coll Cardiol. 2010 Jul 27;56(5):414-22. doi: 10.1016/j.jacc.2010.03.050.

 

Thymosin beta4: a key factor for protective effects of eEPCs in acute and chronic ischemia.

Hinkel R, Bock-Marquette I, Hatzopoulos AK, Kupatt C.

Ann N Y Acad Sci. 2010 Apr;1194:105-11. doi: 10.1111/j.1749-6632.2010.05489.x. Erratum in: Ann N Y Acad Sci. 2010 Sep;1205(1):284. Hazopoulos, Antonis K [corrected to Hatzopoulos, Antonis K].

 

RAGE and ICAM-1 cooperate in mediating leukocyte recruitment during acute inflammation in vivo.

Frommhold D, Kamphues A, Hepper I, Pruenster M, Lukic IK, Socher I, Zablotskaya V, Buschmann K, Lange-Sperandio B, Schymeinsky J, Ryschich E, Poeschl J, Kupatt C, Nawroth PP, Moser M, Walzog B, Bierhaus A, Sperandio M.

Blood. 2010 Aug 5;116(5):841-9. doi: 10.1182/blood-2009-09-244293. Epub 2010 Apr 20.

 

Myocardial transfection of hypoxia inducible factor-1alpha via an adenoviral vector during coronary artery bypass grafting. - A multicenter phase I and safety study -.

Kilian EG, Sadoni S, Vicol C, Kelly R, van Hulst K, Schwaiger M, Kupatt C, Boekstegers P, Pillai R, Channon K, Hetzer R, Reichart B.

Circ J. 2010 May;74(5):916-24. Epub 2010 Mar 10.

 

Nonviral intercellular adhesion molecule-1 small interfering ribonucleic acid sequences transfection in vivo how ultrasound bursts into therapy.

Kupatt C.

J Am Coll Cardiol. 2010 Mar 2;55(9):914-6. doi: 10.1016/j.jacc.2009.10.036. No abstract available.

 

Partial avulsion of prosthetic aortic valve caused by S. epidermidis infection resulting in a giant false aneurysm of the complete thoracic aorta.

Brunner S, Kriegl L, Becker C, Kreuzer E, Reichart B, Näbauer M, Steinbeck G, Kupatt C.

Int J Cardiol. 2011 Aug 4;150(3):e89-91. doi: 10.1016/j.ijcard.2009.11.029. Epub 2010 Jan 6.

 

Transgenic expression of the human A20 gene in cloned pigs provides protection against apoptotic and inflammatory stimuli.

Oropeza M, Petersen B, Carnwath JW, Lucas-Hahn A, Lemme E, Hassel P, Herrmann D, Barg-Kues B, Holler S, Queisser AL, Schwinzer R, Hinkel R, Kupatt C, Niemann H.

Xenotransplantation. 2009 Nov-Dec;16(6):522-34. doi: 10.1111/j.1399-3089.2009.00556.x.

 

NF kappaB activation in embryonic endothelial progenitor cells enhances neovascularization via PSGL-1 mediated recruitment: novel role for LL37.

Pfosser A, El-Aouni C, Pfisterer I, Dietz M, Globisch F, Stachel G, Trenkwalder T, Pinkenburg O, Horstkotte J, Hinkel R, Sperandio M, Hatzopoulos AK, Boekstegers P, Bals R, Kupatt C.

Stem Cells. 2010 Feb;28(2):376-85. doi: 10.1002/stem.280.