Lehrstuhl für

Regenerative Medizin

Prof. Dr.
Alessandra Moretti
Lehrstuhl für Regenerative Medizin kardiovaskulärer Erkrankungen
+ 49 89 4140 2947

Regenerative Medizin kardiovaskulärer Erkrankungen


Suppression of Arrhythmia by Enhancing Mitochondrial Ca2+ Uptake in Catecholaminergic Ventricular Tachycardia Models.

Schweitzer MK, Wilting F, Sedej S, Dreizehnter L, Dupper NJ, Tian Q, Moretti A, My I, Kwon O, Priori SG, Laugwitz KL, Storch U, Lipp P, Breit A, Mederos Y Schnitzler M, Gudermann T, Schredelseker J.

JACC Basic Transl Sci. 2017 Dec;2(6):737-747. doi: 10.1016/j.jacbts.2017.06.008. Epub 2017 Nov 8.


Free PMC Article

Perspectives and Challenges of Pluripotent Stem Cells in Cardiac Arrhythmia Research.

Goedel A, My I, Sinnecker D, Moretti A.

Curr Cardiol Rep. 2017 Mar;19(3):23. doi: 10.1007/s11886-017-0828-z. Review.


Subtype-specific promoter-driven action potential imaging for precise disease modelling and drug testing in hiPSC-derived cardiomyocytes.

Chen Z, Xian W, Bellin M, Dorn T, Tian Q, Goedel A, Dreizehnter L, Schneider CM, Ward-van Oostwaard D, Ng JK, Hinkel R, Pane LS, Mummery CL, Lipp P, Moretti A, Laugwitz KL, Sinnecker D.

Eur Heart J. 2017 Jan 21;38(4):292-301. doi: 10.1093/eurheartj/ehw189. No abstract available.


Free PMC Article

Elucidating arrhythmogenic mechanisms of long-QT syndrome CALM1-F142L mutation in patient-specific induced pluripotent stem cell-derived cardiomyocytes.

Rocchetti M, Sala L, Dreizehnter L, Crotti L, Sinnecker D, Mura M, Pane LS, Altomare C, Torre E, Mostacciuolo G, Severi S, Porta A, De Ferrari GM, George AL Jr, Schwartz PJ, Gnecchi M, Moretti A, Zaza A.

Cardiovasc Res. 2017 Apr 1;113(5):531-541. doi: 10.1093/cvr/cvx006.


Diabetes Mellitus-Induced Microvascular Destabilization in the Myocardium.

Hinkel R, Howe A, Renner S, Ng J, Lee S, Klett K, Kaczmarek V, Moretti A, Laugwitz KL, Skroblin P, Mayr M, Milting H, Dendorfer A, Reichart B, Wolf E, Kupatt C.

J Am Coll Cardiol. 2017 Jan 17;69(2):131-143. doi: 10.1016/j.jacc.2016.10.058.

A new hERG allosteric modulator rescues genetic and drug-induced long-QT syndrome phenotypes in cardiomyocytes from isogenic pairs of patient induced pluripotent stem cells.

Sala L, Yu Z, Ward-van Oostwaard D, van Veldhoven JP, Moretti A, Laugwitz KL, Mummery CL, IJzerman AP, Bellin M.

EMBO Mol Med. 2016 Sep 1;8(9):1065-81. doi: 10.15252/emmm.201606260.


Functional comparison of induced pluripotent stem cell- and blood-derived GPIIbIIIa deficient platelets.

Orban M, Goedel A, Haas J, Sandrock-Lang K, Gärtner F, Jung CB, Zieger B, Parrotta E, Kurnik K, Sinnecker D, Wanner G, Laugwitz KL, Massberg S, Moretti A

PLoS One. 2015 Jan 21;10(1):e0115978. doi: 10.1371/journal.pone.0115978.

Subtype-specific promoter-driven action potential imaging for precise disease modelling and drug testing in hiPSC-derived cardiomyocytes.

Chen Z1, Xian W2, Bellin M3, Dorn T1, Tian Q2, Goedel A1, Dreizehnter L1, Schneider CM1, Ward-van Oostwaard D3, Ng JK1, Hinkel R4, Pane LS1, Mummery CL3, Lipp P2, Moretti A5, Laugwitz KL5, Sinnecker D6.

Bott-Flügel L, Weig H-J, Knödler M, Städele C, Moretti A, Laugwitz K-L & Seyfarth M (2005). Gene transfer of the pancaspase inhibitor p35 reduces myocardial infarct size and improves cardiac function. J. Mol. Med.83: 526-534.

Qyang Y, Martin-Puig S, Chiravuri M, Chen S, Xu H, Bu L, Jiang X, Lin L, Granger A, Moretti A, Caron L, Wu X, Clarke J, Taketo MM, Laugwitz K-L, Moon RT, Gruber P, Evans SM, Ding S & Chien KR (2007). The renewal and differentiation of Isl1+ cardiovascular progenitors are controlled by a Wnt/β-catenin pathway. Cell Stem Cell1: 1-15. 

Moretti A, Bellin M, Jung CB, Thies T, Takashima Y, Bernshausen A, Schiemann M, Fisher S, Moosmang S, Smith AG, Lam JT & Laugwitz KL (2010). Mouse and human induced pluripotent stem cells as a source for multipotent Isl1+ cardiovascular progenitors. FASEB J. 24: 700-711.

Onorati M, Camnasio S, Binetti M, Jung CB, Moretti A & Cattaneo E (2010). Generation of neuropotent self-renewing neuronal stem (NS) cells from muose fobroblast-derived induced pluripotent stem (iPS) cells. Mol. Cell. Neurosci.43: 287-295. 

Lam JT, Moretti A & Laugwitz K-L (2010). Multipotent Progenitor Cells in Regenerative Medicine. In : Heart Regeneration: Stem Cells and Beyond. Editores F. Engel, T. Braun and A.F. Moorman. World Scientifi Publishing Co. Pte. Ltd., Singapore.

Moretti A, Bellin M, Welling A, Jung CB, Lam JT, Bott-Flügel L, Dorn T, Gödel A, Höhnke C, Hofmann F, Seyfarth M, Sinnecker D, Schömig A & Laugwitz K-L (2010). Patient-specific induced pluripotent stem cell models for long-QT syndrome. N. Engl. J. Med. 363: 1397-409. 

Jung CB, Moretti A, Schnitzler MM, Iop L, Storch U, Bellin M, Dorn T, Ruppenthal S, Pfeiffer S, Goedel A, Dirschinger RJ, Seyfarth M, Lam JT, Sinnecker D, Gudermann T, Lipp P & Laugwitz K-L (2012). Dantrolene rescues arrhythmogenic RYR2 defect in a patient-specific stem cell model of catecholaminergic polymorphic ventricular tachycardia. EMBO Mol. Med.3:180-191. 

Zhang H, Zou B, Yu H, Moretti A, Wang X, Yan W, Babcock JJ, Bellin M, McManus OB, Tomaselli G, Nan F, Laugwitz K-L & Li M (2012). Modulation of hERG potassium channel gating normalizes action potential duration prolonged by dysfunctional KCNQ1 potassium channel. Proc. Natl. Acad. Sci. USA.109:11866–11871.


Reviews und Editorials

Chien KR, Moretti A & Laugwitz K-L (2004). ES cells to the Rescue. Science306: 239-240.

Moretti A, Lam J, Evans S, & Laugwitz K-L (2007). Cardiovascular development towards biomedical applicability: Biology of Isl1+ cardiac progenitor cells in development and disease. Cell. Mol. Life Sci. 64: 674-682.

Laugwitz K-L, Moretti A, Nakano A & Chien KR (2008). Islet-1 Cardiovascular Progenitors: A single source for heart lineages? Development 135: 193-205.

Lam JT, Moretti A & Laugwitz KL (2009). Multipotent progenitor cells in regenerative cardiovascular medicine. Pediatr. Cardiol.30: 690-8.

Evans SM, Moretti A & Laugwitz KL (2010). MicroRNAs in a cardiac loop: progenitor or myocyte? Dev. Cell19: 787-8.

Dirschinger RJ, Goedel A, Moretti A, Laugwitz KL & Sinnecker D (2012). Recapitulating Long-QT syndrome using induced pluripotent stem cell technology. Pediatr. Cardiol.33:950-8

Sinnecker D, Dirschinger RJ, Goedel A, Moretti A, Lipp P & Laugwitz KL. Induced pluripotent stem cells in cardiovascular research. Rev. Physiol. Biochem. Pharmacol. 2012 Mar 24. [Epub ahead of print]